The idea for “Brain – bit by bit” came to my mind about 15 years ago.
As a senior resident I reported an MRI of the brain of a patient with the cortex looking diffusely abnormal. There was a comparative scan, made 5 years earlier, briefly after the new 3T scanner had been set up in our hospital. This initial scan had been interpreted as normal by the professor in neuroradiology, a very knowledgeable doctor. Although the diffuse cortical abnormality was already visible, it was not recognised because inexperience with the 3T image.
Neuroradiology requires not only familiarity with the normal (MR) image but also understanding of the (patho)physiology. Whenever the physiology of the brain becomes too complicated for me, I go back in embryology to the neural tube, before the neurons and glial cells started to move and intertwine.
In Brain bit by bit vlogs I would like to share and show what I learned and know about different brain diseases, commenting on the radiological macroscopic picture and discussing what happened and happens at the microscopic, invisible cell level. Because this knowledge enables not only recognition of focal, obvious lesions in the brain but also diffuse, subtle disease that has just as much impact on life.
If you want to correct or add a little bit, that is appreciated.
The patient turned out to have an iron metabolism disorder and the first scan was “pre” electroconvulsive therapy.
Brain - bit by bit 